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Neurodegenerative Disorders >> Primary Lateral Sclerosis

Disease Description:
Motor neuron diseases are disorders in which nerve cells that control voluntary muscles undergo degeneration. Amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and progressive muscle atrophy (PMA) are examples. Some motor neuron diseases affect the lower motor neurons in the spinal cord. Others affect the upper motor neurons in the brain. Motor neuron diseases cause muscles to become weak. This leads to problems with walking, hand movements, or breathing.

General Study Procedures:
The research studies listed below are currently open for enrollment for adult subjects. Clinical examinations, neurophysiological testing, imaging, and neuropsychological tests are used to better understand motor neuron diseases. Please see the links for the procedures and eligibility criteria for specific studies. There is no cost for participation or for any tests associated with the research.

Studies Actively Recruiting Patients:
01-N-0145: Screening and Natural History: Primary Lateral Sclerosis and Related Disorders

For more information about participating in these studies, please contact :
For protocol 01-N-0145
Patient Recruitment and Public Liaison Office (PRPL)
NIH, DHHS
Bldg. 61, #10 Cloister court
Bethesda, MD 20892-4754
Tel: 800-411-1222; 866-411-1010 (TTY)
Email: prpl@mail.cc.nih.gov

or
Patient Recruitment and Public Liaison Office toll-free at:
1-800-411-1222
TTY: 1-866-411-1010

For more information on Primary Lateral Sclerosis:


NINDS HOME ACCESSIBILITY INFORMATION NINDS AT THE CLINICAL CENTER PRIVACY STATEMENT RECRUITMENT CONTACT
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