National Clinical Center
Search: 
 
Home Disorders Clinical Center
 

Movement Disorders
Neuroimmunology
Stroke and Vascular Disorders
Epilepsy
Memory Disorders & Dementia
Familial & Hereditary Disorders
Neurosurgical Disorders & Brain Tumors
Neurodegenerative Disorders
Brain Injury
Neuromuscular Disorders
Neurological Disorders of Children

Movement Disorders >> Dystonia

Disease Description:
Dystonia is a condition in which muscles contract involuntarily. It often leads to twisted postures of the head, arms or legs. There are different kinds of dystonia. Some affect the entire body while some affect only one part of the body. In task-specific dystonia, the involuntary contractions occur only when carrying out particular tasks, such as writing (writer’s cramp) or playing a musical instrument (musician’s cramp). In blepharospasm, uncontrollable blinking of the eyelids is the most common. The causes of dystonia are not well understood. The research focuses on finding the causes and better forms of experimental treatment.

General Study Procedures:
The research studies listed below are currently open for enrollment for adult subjects. They may involve physiological studies to measure the activity in the brain and the muscles; imaging studies such as MRI of the brain while carrying out movements; PET studies of neurotransmitters; and experimental treatment studies with retraining techniques or injections of botulinum toxin. Please see the links below for the procedures and eligibility criteria for specific studies. There is no cost for participation or for any tests associated with the research.

Studies Actively Recruiting Patients:
02-N-0132: Brain Anatomy in Dystonia
05-N-0228: Movement-Related Brain Networks Involved in Hand Dystonia
07-N-0187: Brain Function in Performance of Motor Tasks
11-N-0211: Deep brain stimulation surgery for movement disorders
12-N-0104: Validating a New Writer's Cramp Scale
13-N-0022: Acetyl Hexapeptide-8 for Blepharospasm
13-N-0076: Transcranial Magnetic Stimulation for Focal Hand Dystonia
13-N-0163: Investigating the plastic effects of repetitive paired associative stimulation (rPAS) in dystonia
14-N-0070: Depotentiation in People With Focal Hand Dystonia

For more information about participating in these studies, please contact :
For protocol 12-N-0104 or 14-N-0070 or 13-N-0076 or 02-N-0132 or 05-N-0228 or 07-N-0187 or 13-N-0022
Elaine Considine, R.N.
MNB, NINDS
Bldg. 10, Room 7D36A
10 Center Drive, MSC 1428
Bethesda, MD 20892-1428
Tel: 301 435 8518
Email: considinee@ninds.nih.gov

For protocol 11-N-0211
SNBrecruiting@nih.gov

Tel:
Email: SNBrecruiting@nih.gov

For protocol 13-N-0163
Jennifer Farren, RN, BSN, MA (C)

Tel: 301 451 1229
Email: jennifer.farren@nih.gov

or
Patient Recruitment and Public Liaison Office toll-free at:
1-800-411-1222
TTY: 1-866-411-1010

For more information on Dystonia:


NINDS HOME ACCESSIBILITY INFORMATION NINDS AT THE CLINICAL CENTER PRIVACY STATEMENT RECRUITMENT CONTACT
U.S. Department of Health & Human Services National Institutes of Health National Institute of Neurological Disorders and Stroke The U.S. Government's Official Web Portal