Disease Description:

HTLV-I-associated myelopathy/Tropical spastic paraparesis (HAM/TSP) is a chronic and progressive inflammatory disease of the central nervous system. It causes progressive weakness, stiff muscles, and muscle spasms. HAM/TSP is caused by infection with the human T-cell lymphotropic virus-1 (HTLV-1) retrovirus.

General Study Procedures:

The research studies listed below are currently open for enrollment for adult subjects. These involve neurological examinations, imaging, and assessment of the immune system to better understand and treat HAM/TSP. Please see the links for the procedures and eligibility criteria for specific studies. There is no cost for participation or for any tests associated with the research.

Studies Actively Recruiting Patients:

04-N-0071: Hu Mik-(Beta)1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

98-N-0047: Evaluation of Patients With HAM/TSP

For more information about participating in these studies, please contact :
For protocol 04-N-0071 Joan Ohayon, CRNP NINDS, NIB Bldg. 10, Room 5C101 10 Center Drive, MSC 1400 Bethesda, MD 20892-1400 Tel: 301-496-0064 Email: ohayonj@ninds.nih.gov
For protocol 98-N-0047 Kaylan Fenton Bldg. 10, Room 5C101 10 Center Dr., MSC 1400 Bethesda, MD 20892-1400 Tel: 301-496-0064 Email: fentonk@ninds.nih.gov
or
Patient Recruitment and Public Liaison Office toll-free at: 1-800-411-1222 TTY: 1-866-411-1010

For more information on Tropical Spastic Paraparesis - HAM/TSP:

http://www.ninds.nih.gov/disorders/tropical_spastic_paraparesis/tropical_spastic_paraparesis.htm

Related Links:

ClinicalTrials.gov